Browsing by Author "Russell, David H"
Now showing items 1-20 of 26
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Mallis, Christopher S (2021-08-18)Native mass spectrometry (nMS) is an expanding technique whereby ions with low internal energies are ionized and non-covalent structural elements remain intact following desolvation from solution-phase molecules to ...
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Shirzadeh, Mehdi (2020-04-14)The proposed mechanism of fibril formation of transthyretin (TTR) involves self-assembly of partially unfolded monomers. However, the mechanism(s) of disassembly to monomer and potential intermediates involved in this ...
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Brawley, Hayley N (2021-06-01)Low-molecular-mass (LMM) transition metal complexes are thought to play essential roles in metal ion trafficking, regulation, and signaling in biological systems. Their chemical identities remain largely unknown due to ...
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Gill, Jason J; Berry, Joel D; Russell, William K; Lessor, Lauren; Escobar-Garcia, Diego A; Hernandez, Daniel; Kane, Ashley; Keene, Jennifer; Maddox, Matthew; Martin, Rebecca; Mohan, Sheba; Thorn, Ashlyn M; Russell, David H; Young, Ry (BMC Genomics, 2012)
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Werke, Carrie Beth (2014-08-27)Graphene and graphite are materials of high interest for many applications. In order to increase the possible uses of these materials, more must be understood about how their properties can be modified. One way to modify ...
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Jeon, Junho (2013-10-16)A novel ion mobility-mass spectrometer was designed and built in order to achieve high transmission and high resolution for observing desolvated ion conformations of chemical and biological molecules in the gas phase. The ...
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Fort, Kyle Logan (2014-12-09)Ion mobility-mass spectrometry (IM-MS) provides gas phase, size-based separation, on an ultrafast timescale (μs-ms). With the incorporation of electrospray ionization, IM-MS is a valuable tool to investigate conformations ...
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Fan, Licheng (2020-06-24)Lipids are a group of biomolecules which play crucial roles in many biological functions such as cell membrane construction, energy storage, and signal transduction. The aberrant metabolism of lipids is involved in the ...
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Xiao, Chunying (2015-10-02)The effects of charge states, charge sites and side chain interactions on conformational preferences of gas phase peptide ions are examined by ion mobility-mass spectrometry (IM-MS) and molecular dynamics (MD) simulations. ...
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Tuvilla, Mavreen Rose (2013-05-08)The three dimensional structure of a protein is important for its function. When misfolded, a protein may be rendered inactive or adapt a conformation that could be toxic. Studying protein folding requires an understanding ...
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Niu, Lili (2009-05-15)A lot of things happen to proteins when Escherichia coli cells enter stationary phase, such as protein amount, post-translational modifications, conformation changes, and component of protein complex. Proteomics, which ...
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Wagner, Nicole DeAnne (2017-08-02)Native electrospray ionization ion mobility mass spectrometry (ESI-IM-MS) allows for the investigation of complex heterogeneous mixtures of intact biomolecules according to their mass, charge, and size, which can provide ...
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Hebert, Michael James (2020-06-22)The ability to retain and observe solution-phase structures using the gas-phase ion mobility (IM) technique is paradoxical. Although many studies have shown kinetic trapping during electrospray ionization (ESI) can allow ...
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Gomez Hernandez, Mario 1980- (2012-07-11)Functionalized nanoparticles provide a wide range of potential applications for Biological Mass Spectrometry (MS). Particularly, we have studied the effects of chromophore activity on the performance of gold nanoparticles ...
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Champion, Matthew Maurice (Texas A&M University, 2006-04-12)Cells respond to their environment with programmed changes in gene expression. Cataloging these changes at the protein level is key towards understanding the physiology of an organism. Multi-subunit and multi-protein ...
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Cong, Xiao (2015-04-24)Phosphatidylserine (PS) lipids in cell membranes play significant roles in cell apoptosis, blood clotting and neurodegenerative disorders such as Alzheimer’s disease (AD). A novel fluorescence quenching assay based on lipid ...
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Interrogation of the Fe-S Cluster Biosynthetic Mechanism Using Native Mass Spectrometric Techniques Lin, Cheng-Wei (2021-07-06)Iron-sulfur (Fe-S) clusters are ubiquitous protein cofactors that are required for important biological processes including oxidative respiration, nitrogen fixation, and photosynthesis. Defects on Fe-S cluster assembly ...
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Servage, Kelly Anne (2016-07-28)Electrospray ionization (ESI) combined with ion mobility-mass spectrometry (IMMS) provides a means to directly measure the three-dimensional shape(s) of intact biomolecular ions allowing for the structural investigation ...
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Geng, Sheng (2017-02-10)It has been shown that secondary ion emission from ultra-thin foils is notably enhanced in the transmission direction. This feature should be of interest for examining nano-objects. A pre-requisite is to deposit them on ...
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Schrecke, Samantha Rose (2022-05-18)Two-pore potassium channels (K₂ᴘ) are leak channels responsible for maintaining the resting membrane potential. While they are known to be activated by lysophospholipids and particularly sensitive to their lipid environment ...